There is a large body of research reporting blueberry and its positive effects on age-related neuronal function and behavior. Pigs, which are a suitable model for human digestive absorption, were used to examine the deposition of anthocyanins in tissues including the liver, eye, and brain tissue. After 4 weeks of consuming a blueberry-supplemented diet, the pigs were fasted and euthanized. Although no anthocyanins were detected in the plasma, or urine of the fasted animals, intact anthocyanins were detected in all tissues where they were sought. The results suggest that anthocyanins can accumulate in tissues, including tissues beyond the blood-brain barrier.
Kalt, W., Blumberg, J.B., McDonald, J.E., Vinqvist-Tymchuk, M.R., Fillmore, S.A.E., Graf, B.A., O’Leary, J.M., Milbury, P.E. 2008. Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs. J.Agric Food Chem. 56: 705-712